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\u30ea\u30f3\u30af\uff1aEnglish version<\/a>\u30fb\u6a5f\u68b0\u79d1\u5b66\u30b3\u30fc\u30b9\u30a6\u30a7\u30d6\u30b5\u30a4\u30c8<\/a>\u30fb\u30b3\u30fc\u30b9\u7d39\u4ecb\u30ea\u30fc\u30d5\u30ec\u30c3\u30c8<\/a>\u30fb\u57fa\u790e\u5de5website\u7814\u7a76\u7d39\u4ecb<\/a><\/p>\n

\u5f53\u7814\u7a76\u5ba4\u3067\u306f\u300c\u8a08\u6e2c \u00d7 \u6570\u7406\uff65\u7269\u7406\uff65\u7d71\u8a08\uff65\u60c5\u5831\u5b66 \u00d7 \u5206\u5b50\u751f\u7269\u5b66\uff65\u907a\u4f1d\u5b50\u5de5\u5b66\u300d<\/span>\u00a0\u3092\u7d44\u307f\u5408\u308f\u305b\u305f\u5b66\u969b\u7684\u624b\u6cd5\u306b\u57fa\u3065\u304d\u3001\u6975\u3081\u3066\u8907\u96d1\u3067\u5965\u6df1\u3044\u751f\u547d\u73fe\u8c61\u306e\u7406\u89e3\u3001\u65b0\u3057\u3044\u751f\u547d\u7269\u7406\u306e\u958b\u62d3\u3001\u8001\u5316\u8abf\u7bc0\u306a\u3069\u306e\u533b\u7642\u5fdc\u7528\u3092\u76ee\u6307\u3057\u305f\u7814\u7a76\u306b\u53d6\u308a\u7d44\u3093\u3067\u3044\u307e\u3059\u3002<\/span><\/p>\n

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1-1) \u751f\u547d\u306e\u6052\u5e38\u6027\u30fb\u9069\u5fdc\u30fb\u8001\u5316\u306e\u30e1\u30ab\u30cb\u30ba\u30e0<\/strong><\/h3>\n

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\u7d30\u80de\u306f\u751f\u547d\u306e\u6700\u5c0f\u5358\u4f4d\u3067\u3042\u308a\u306a\u304c\u3089\u3001\u6975\u3081\u3066\u9ad8\u3044\u67d4\u8edf\u6027\u3068\u5fdc\u7b54\u6027\u3092\u3082\u3064\u3053\u3068\u304b\u3089\u3001\u751f\u547d\u306e\u539f\u7406\u3092\u7406\u89e3\u3059\u308b\u3046\u3048\u3067\u91cd\u8981\u306a\u7814\u7a76\u5bfe\u8c61\u3067\u3059\u3002\u5f53\u7814\u7a76\u5ba4\u3067\u306f\u3001\u6a5f\u68b0\u79d1\u5b66\u3092\u30d0\u30c3\u30af\u30b0\u30e9\u30a6\u30f3\u30c9\u3068\u3059\u308b\u5b66\u751f\u306b\u5bfe\u3057\u3066\u3082\u3001\u6570\u7406\u30e2\u30c7\u30eb\u3084\u7269\u7406\u7684\u8996\u70b9\u3092\u901a\u3058\u3066\u751f\u547d\u73fe\u8c61\u306b\u30a2\u30d7\u30ed\u30fc\u30c1\u3059\u308b\u6a5f\u4f1a\u3092\u63d0\u4f9b\u3057\u3066\u3044\u307e\u3059\u3002<\/p>\n

\u307e\u305f\u3001\u7d30\u80de\u306e\u7814\u7a76\u3092\u901a\u3058\u3066\u3001\u300c\u8001\u5316\u300d\u3084\u300c\u3053\u3053\u308d\u300d\u306e\u72b6\u614b\u306a\u3069\u3001\u3088\u308a\u9ad8\u6b21\u306e\u751f\u547d\u73fe\u8c61\u306e\u7406\u89e3\u306b\u3082\u53d6\u308a\u7d44\u3093\u3067\u3044\u307e\u3059\u3002\u5b9f\u9a13\u30fb\u7406\u8ad6\u306e\u4e21\u9762\u304b\u3089\u67d4\u8edf\u306a\u624b\u6cd5\u3092\u7528\u3044\u3066\u3001\u591a\u9762\u7684\u306a\u89e3\u6790\u3092\u9032\u3081\u308b\u3053\u3068\u304c\u672c\u7814\u7a76\u5ba4\u306e\u7279\u5fb4\u3067\u3059\u3002<\/p>\n

\u3053\u308c\u307e\u3067\u306b\u3001\u30d0\u30a4\u30aa\u30e1\u30ab\u30cb\u30af\u30b9\u3084\u751f\u547d\u79d1\u5b66\u5206\u91ce\u306e\u4e3b\u8981\u306a\u5b66\u8853\u8a8c\u306b\u304a\u3044\u3066\u591a\u6570\u306e\u7814\u7a76\u6210\u679c\u3092\u767a\u8868\u3057\u3066\u304a\u308a\u3001\u56fd\u969b\u7684\u306a\u7814\u7a76\u767a\u4fe1\u3082\u7a4d\u6975\u7684\u306b\u884c\u3063\u3066\u3044\u307e\u3059\u3002\u8ab2\u984c\u89e3\u6c7a\u578b\u306e\u7814\u7a76\u3092\u901a\u3057\u3066\u3001\u5b66\u751f\u306b\u3068\u3063\u3066\u3082\u81ea\u767a\u7684\u306b\u8003\u3048\u884c\u52d5\u3059\u308b\u529b\u3092\u80b2\u3080\u3053\u3068\u3092\u91cd\u8996\u3057\u3066\u3044\u307e\u3059\u3002<\/p>\n

\u6700\u8fd1\u306e\u95a2\u9023\u8ad6\u6587<\/p>\n

Ueda et al., Sci. Rep.<\/strong><\/em> 12, 14466, 2022.<\/p>\n

Huang et al., Am. J. Physiol. Cell Physiol.<\/strong><\/em> 320, C1153\u2013C1163, 2021.<\/p>\n

Saito et al., Biomech. Model. Mechanobiol.<\/strong><\/em> 20, 155-166, 2021.<\/p>\n

Okamoto et al., Biomech. Model. Mechanobiol.<\/strong><\/em>\u00a019, 543-555, 2020.<\/p>\n

\u2191<\/a><\/p>\n

1-2) \u751f\u547d\u306e\u30e1\u30ab\u30cb\u30af\u30b9\u3068\u30b7\u30b0\u30ca\u30eb\u4f1d\u9054<\/strong><\/h3>\n

\u751f\u547d\u306e\u6052\u5e38\u6027\u3084\u9069\u5fdc\u7684\u5fdc\u7b54\u306e\u30e1\u30ab\u30cb\u30ba\u30e0\u3092\u660e\u3089\u304b\u306b\u3059\u308b\u305f\u3081\u306b\u306f\u3001\u7d30\u80de\u5185\u306e\u69cb\u9020\u7684\u5909\u5316\u3068\u305d\u308c\u306b\u4f34\u3046\u30b7\u30b0\u30ca\u30eb\u4f1d\u9054\u306e\u7406\u89e3\u304c\u4e0d\u53ef\u6b20\u3067\u3059\u3002\u7d30\u80de\u5185\u3067\u306f\u3001\u69cb\u9020\u7269\u306e\u4f4d\u7f6e\u3084\u5f62\u72b6\u304c\u6642\u9593\u3068\u3068\u3082\u306b\u5927\u304d\u304f\u5909\u5316\u3057\u3001\u305d\u308c\u306b\u5fdc\u3058\u3066\u7d30\u80de\u5168\u4f53\u306e\u5fdc\u7b54\u6027\u3084\u9069\u5fdc\u80fd\u529b\u304c\u898f\u5b9a\u3055\u308c\u307e\u3059\u3002\u3053\u308c\u306b\u3088\u308a\u3001\u5916\u90e8\u74b0\u5883\u306e\u5909\u5316\u306b\u5bfe\u3057\u3066\u69cb\u9020\u305d\u306e\u3082\u306e\u3092\u67d4\u8edf\u306b\u5909\u5316\u3055\u305b\u306a\u304c\u3089\u9069\u5fdc\u3059\u308b\u3053\u3068\u304c\u53ef\u80fd\u3067\u3059\u3002\u3053\u306e\u70b9\u306b\u304a\u3044\u3066\u3001\u751f\u4f53\u306f\u30ed\u30dc\u30c3\u30c8\u306a\u3069\u306e\u4eba\u5de5\u7269\u3068\u306f\u672c\u8cea\u7684\u306b\u7570\u306a\u308b\u52d5\u4f5c\u539f\u7406\u3092\u3082\u3063\u3066\u3044\u307e\u3059\u3002<\/p>\n

\u3053\u3046\u3057\u305f\u69cb\u9020\u5909\u5316\u3084\u7269\u8cea\u8f38\u9001\u3092\u89e3\u6790\u3059\u308b\u305f\u3081\u306b\u3001\u5f53\u7814\u7a76\u5ba4\u3067\u306f\u56fa\u4f53\u529b\u5b66\u3084\u6750\u6599\u529b\u5b66\u306b\u57fa\u3065\u304f\u5909\u5f62\u89e3\u6790\u3001\u306a\u3089\u3073\u306b\u62e1\u6563\u30fb\u6d41\u308c\u3092\u8a18\u8ff0\u3059\u308b\u6d41\u4f53\u529b\u5b66\u3084\u53cd\u5fdc\u62e1\u6563\u7cfb\u306e\u6570\u7406\u30e2\u30c7\u30eb\u3092\u6d3b\u7528\u3057\u3066\u3044\u307e\u3059\u3002\u307e\u305f\u3001\u751f\u4f53\u306e\u968e\u5c64\u6027\u3092\u8003\u616e\u3057\u305f\u30b7\u30b9\u30c6\u30e0\u8ad6\u30fb\u5236\u5fa1\u7406\u8ad6\u306b\u3088\u308b\u89e3\u6790\u306b\u3082\u53d6\u308a\u7d44\u3093\u3067\u3044\u307e\u3059\u3002\u7d30\u80de\u5185\u3067\u306e\u73fe\u8c61\u306f\u3001\u53cd\u5fdc\u30fb\u79fb\u52d5\u30fb\u5909\u5f62\u3068\u3044\u3063\u305f\u8907\u6570\u306e\u7269\u7406\u904e\u7a0b\u304c\u76f8\u4e92\u306b\u95a2\u4e0e\u3059\u308b\u300c\u30de\u30eb\u30c1\u30d5\u30a3\u30b8\u30c3\u30af\u30b9\u7cfb\u300d\u3067\u3042\u308a\u3001\u7406\u8ad6\u30fb\u6570\u5024\u30fb\u5b9f\u9a13\u306e\u591a\u9762\u7684\u624b\u6cd5\u3092\u7d44\u307f\u5408\u308f\u305b\u3066\u7d71\u5408\u7684\u306b\u7406\u89e3\u3092\u9032\u3081\u3066\u3044\u307e\u3059\u3002<\/p>\n

\u6700\u8fd1\u306e\u95a2\u9023\u8ad6\u6587<\/p>\n

Chantachotikul et al., Cell. Signal.<\/strong><\/em>\u00a0127, 111616, 2025.<\/p>\n

Ding et al., eLife<\/strong><\/em>, 105236.1, 2025<\/p>\n

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Kang et al., Mol. Biol. Cell<\/strong><\/em> 32, ar28, 1-12, 2021.<\/p>\n

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Fujiwara et al., J. Cell Sci.<\/strong><\/em> 24, 390-402, 2019.<\/p>\n

Matsui and Deguchi, Am. J. Physiol. Cell Physiol.<\/strong><\/em> 316, C509-521, 2019<\/p>\n

\u2191<\/a><\/p>\n

1-3) \u7d30\u80de\u6a5f\u80fd\u8a08\u6e2c\u6280\u8853\u306e\u958b\u767a<\/strong><\/h3>\n

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\u5f93\u6765\u306eTraction Force Microscopy\uff08TFM\uff09\u306f\u3001\u7d30\u80de\u304c\u57fa\u8cea\u306b\u52a0\u3048\u308b\u529b\u3092\u8a08\u6e2c\u3059\u308b\u6709\u529b\u306a\u6280\u8853\u3067\u3059\u304c\u3001\u86cd\u5149\u6a19\u8b58\u3084\u7279\u6b8a\u306a\u64ae\u50cf\u30fb\u89e3\u6790\u5de5\u7a0b\u3092\u5fc5\u8981\u3068\u3059\u308b\u305f\u3081\u3001\u64cd\u4f5c\u306e\u7169\u96d1\u3055\u3084\u4f4e\u30b9\u30eb\u30fc\u30d7\u30c3\u30c8\u6027\u304c\u8ab2\u984c\u3068\u306a\u3063\u3066\u3044\u307e\u3057\u305f\u3002\u3053\u308c\u306b\u5bfe\u3057\u5f53\u7814\u7a76\u5ba4\u3067\u306f\u3001\u7d30\u80de\u304c\u67d4\u3089\u304b\u3044\u57fa\u677f\u306b\u5f62\u6210\u3059\u308b\u5fae\u7d30\u306a\u76ba\uff08wrinkle\uff09\u30d1\u30bf\u30fc\u30f3\u3092\u753b\u50cf\u30d9\u30fc\u30b9\u3067\u89e3\u6790\u3057\u3001\u305d\u3053\u304b\u3089\u6a5f\u68b0\u5b66\u7fd2\u306b\u3088\u3063\u3066\u529b\u306e\u5206\u5e03\u3092\u63a8\u5b9a\u3059\u308b\u65b0\u305f\u306a\u30a2\u30d7\u30ed\u30fc\u30c1\u3092\u69cb\u7bc9\u3057\u3066\u304d\u307e\u3057\u305f\u3002<\/p>\n

\u3053\u306e\u624b\u6cd5\u306f\u3001\u5f93\u6765\u306eTFM\u3068\u540c\u7b49\u306e\u60c5\u5831\u3092\u3001\u3088\u308a\u7c21\u4fbf\u304b\u3064\u9ad8\u901f\u306b\u53d6\u5f97\u3059\u308b\u3053\u3068\u304c\u53ef\u80fd\u3067\u3042\u308a\u3001\u5275\u85ac\u30b9\u30af\u30ea\u30fc\u30cb\u30f3\u30b0\u3084\u30d5\u30a7\u30ce\u30bf\u30a4\u30d7\u89e3\u6790\u306a\u3069\u3078\u306e\u5fdc\u7528\u304c\u671f\u5f85\u3055\u308c\u307e\u3059\u3002\u7814\u7a76\u5ba4\u3067\u306f\u3001\u753b\u50cf\u51e6\u7406\u3001AI\u6280\u8853\u3001\u6750\u6599\u8a2d\u8a08\u3001\u529b\u5b66\u89e3\u6790\u306a\u3069\u306e\u8907\u6570\u5206\u91ce\u3092\u6a2a\u65ad\u3059\u308b\u5f62\u3067\u3053\u306e\u8a08\u6e2c\u7cfb\u3092\u6539\u826f\u30fb\u767a\u5c55\u3055\u305b\u3066\u304a\u308a\u3001\u3053\u306e\u3088\u3046\u306b\u57fa\u790e\u79d1\u5b66\u306e\u767a\u5c55\u306b\u8ca2\u732e\u3059\u308b\u3068\u3068\u3082\u306b\u3001\u793e\u4f1a\u7684\u30cb\u30fc\u30ba\u306b\u5fdc\u3048\u308b\u5b9f\u8df5\u7684\u306a\u6280\u8853\u958b\u767a\u306b\u3082\u6ce8\u529b\u3057\u3066\u3044\u307e\u3059\u3002<\/p>\n

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Okabe et al., Biophys. J.<\/strong><\/em> 124, 4205-4214, 2025.<\/p>\n

Li et al., PLOS Comput. Biol.<\/strong><\/em> 20(8), e1012312, 2024.<\/p>\n

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Saito et al., Exp. Cell Res.<\/strong><\/em> 404, 112619, 2021.<\/p>\n

\u2191<\/a><\/p>\n

2) \u7d30\u80de\u904a\u8d70\u30fb\u751f\u7269\u904a\u6cf3\u30fb\u96c6\u56e3\u904b\u52d5\u306e\u30bd\u30d5\u30c8\u30de\u30bf\u30fc\u7269\u7406<\/b><\/h3>\n

\u751f\u7269\u306f\u591a\u6570\u306e\u500b\u4f53\u304c\u5354\u8abf\u3057\u3066\u52d5\u4f5c\u3059\u308b\u3053\u3068\u3067\u96c6\u56e3\u3068\u3057\u3066\u7279\u5fb4\u7684\u306a\u632f\u308b\u821e\u3044\u3092\u898b\u305b\u307e\u3059\u3002\u4f8b\u3048\u3070\u9b5a\u30fb\u9ce5\u30fb\u7f8a\u306e\u7fa4\u308c\u306f\u4e00\u4f53\u4e00\u4f53\u305d\u308c\u305e\u308c\u304c\u500b\u5225\u306e\u610f\u601d\u3092\u6301\u3063\u3066\u3044\u308b\u306b\u3082\u95a2\u308f\u3089\u305a\u3001\u96c6\u56e3\u3068\u3057\u3066\u3082\u307e\u308b\u3067\u4e00\u4f53\u306e\u751f\u7269\u304b\u306e\u3088\u3046\u306b\u8868\u60c5\u8c4a\u304b\u306a\u52d5\u304d\u3092\u898b\u305b\u307e\u3059\u3002\u3053\u308c\u3089\u306f\u751f\u7269\u306e\u96c6\u56e3\u904b\u52d5\u3068\u547c\u3070\u308c\u3001\u53e4\u304f\u3088\u308a\u3053\u308c\u3089\u306e\u96c6\u56e3\u904b\u52d5\u3092\u7c21\u7d20\u306a\u6570\u5b66\u30fb\u7269\u7406\u30e2\u30c7\u30eb\u3067\u518d\u73fe\u3057\u3088\u3046\u3068\u76db\u3093\u306b\u7814\u7a76\uff08\u4f8b\u3048\u3070 Vicsek\u30e2\u30c7\u30eb (1995) etc\uff09\u304c\u884c\u308f\u308c\u3066\u304d\u307e\u3057\u305f\u3002\u9855\u5fae\u93e1\u3092\u8997\u3044\u305f\u5c0f\u3055\u3044\u30b9\u30b1\u30fc\u30eb\u306b\u304a\u3044\u3066\u3082\u3001\u7d30\u80de\u3084\u5fae\u751f\u7269\u306a\u3069\u304c\u96c6\u56e3\u904b\u52d5\u3092\u6709\u52b9\u6d3b\u7528\u3057\u5927\u304d\u306a\u30b9\u30b1\u30fc\u30eb\u306e\u73fe\u8c61\u3092\u751f\u307f\u51fa\u3057\u3066\u304a\u308a\u3001\u3053\u308c\u3089\u73fe\u8c61\u3092\u89e3\u660e\u3059\u308b\u305f\u3081\u30bd\u30d5\u30c8\u30de\u30bf\u30fc\u7269\u7406\u30fb\u30a2\u30af\u30c6\u30a3\u30d6\u30de\u30bf\u30fc\u7269\u7406\u306e\u7814\u7a76\u304c\u8fd1\u5e74\u76db\u3093\u306b\u306a\u3063\u3066\u304d\u307e\u3057\u305f\u3002
\n\u79c1\u305f\u3061\u306f\u6d41\u4f53\u529b\u5b66\u30fb\u6750\u6599\u529b\u5b66\u3092\u306f\u3058\u3081\u3068\u3059\u308b\u6a5f\u68b0\u79d1\u5b66\u306e\u77e5\u898b\u304b\u3089\u3001\u7d30\u80de\u3084\u5fae\u751f\u7269\u306e\u500b\u5225\u306e\u52d5\u304d\u30fb\u96c6\u56e3\u904b\u52d5\u306e\u89e3\u6790\u3092\u884c\u3063\u3066\u3044\u307e\u3059\u3002<\/p>\n

\u307e\u305f\u672c\u7814\u7a76\u5ba4\u306f\u751f\u7269\u306b\u7531\u6765\u3059\u308b\u3082\u306e\u3060\u3051\u3067\u306a\u304f\u3001\u78c1\u6027\u56de\u8ee2\u5b50\u306b\u95a2\u3059\u308b\u96c6\u56e3\u904b\u52d5\u306b\u3064\u3044\u3066\u3082\u7814\u7a76\u3092\u884c\u3063\u3066\u3044\u307e\u3059\u3002\u5c0f\u3055\u306a\u78c1\u77f3\u306b\u5916\u90e8\u304b\u3089\u78c1\u5834\u3092\u52a0\u3048\u5168\u3066\u306b\u540c\u4e00\u306e\u52d5\u304d\u3092\u6307\u793a\u3059\u308b\u3053\u3068\u306f\u5bb9\u6613\u3067\u3059\u304c\u3001\u7570\u306a\u308b\u52d5\u4f5c\u3092\u6307\u793a\u3059\u308b\u306e\u306f\u56f0\u96e3\u3068\u8003\u3048\u3089\u308c\u3066\u304d\u307e\u3057\u305f\u3002\u79c1\u305f\u3061\u306f\u78c1\u6c17\u56de\u8ee2\u5b50\u306b\u632f\u52d5\u78c1\u5834\uff08Matsunaga et al., 2019\uff09\u3084\u56de\u8ee2\u78c1\u5834\uff08Kawai, Matsunaga et al., 2020\uff09\u3092\u8ca0\u8377\u3057\u3001\u305d\u306e\u96c6\u56e3\u904b\u52d5\u3092\u5236\u5fa1\u3059\u308b\u65b9\u6cd5\u8ad6\u3092\u63d0\u6848\u3057\u307e\u3057\u305f\u3002<\/p>\n

\u6700\u8fd1\u306e\u95a2\u9023\u8ad6\u6587<\/p>\n

Tokoro et al., Physical Review Fluids<\/strong><\/em> 11, 023102, 2026.<\/p>\n

Kawai et al.,\u00a0Soft Matter<\/strong><\/em>\u00a016 (28), 6484-6492, 2020.<\/p>\n

Matsunaga et al.,\u00a0Nat. Commun.<\/strong><\/em>\u00a010, 4696, 2019.<\/p>\n

\u2191<\/a><\/p>\n

3) \u30e1\u30ab\u30ce\u30a4\u30f3\u30d5\u30a9\u30de\u30c6\u30a3\u30af\u30b9\u3068\u5275\u85ac<\/b><\/h3>\n

\u5f53\u7814\u7a76\u5ba4\u3067\u306f\u3001\u7d30\u80de\u304c\u74b0\u5883\u4e2d\u306e\u529b\u5b66\u7684\u523a\u6fc0\u306b\u5fdc\u7b54\u3059\u308b\u4ed5\u7d44\u307f\u3092\u89e3\u660e\u3059\u308b\u305f\u3081\u3001\u7269\u7406\u7684\u306a\u666e\u904d\u6027\u3068\u5206\u5b50\u7d30\u80de\u751f\u7269\u5b66\u7684\u306a\u5177\u4f53\u6027\u306e\u4e21\u9762\u304b\u3089\u30a2\u30d7\u30ed\u30fc\u30c1\u3057\u3066\u3044\u307e\u3059\u3002\u751f\u547d\u73fe\u8c61\u306b\u304a\u3044\u3066\u300c\u529b\u300d\u306f\u4e2d\u5fc3\u7684\u306a\u5f79\u5272\u3092\u679c\u305f\u3057\u307e\u3059\u304c\u3001\u7269\u7406\u5b66\u304c\u76ee\u6307\u3059\u62bd\u8c61\u7684\u306a\u4e00\u822c\u5316\u306e\u307f\u3067\u306f\u3001\u75be\u60a3\u7406\u89e3\u3084\u6cbb\u7642\u3078\u306e\u5fdc\u7528\u306b\u306f\u9650\u754c\u304c\u3042\u308a\u307e\u3059\u3002\u305d\u3053\u3067\u3001\u73fe\u8c61\u3092\u652f\u3048\u308b\u7269\u7406\u7684\u539f\u7406\u306b\u52a0\u3048\u3066\u3001\u305d\u308c\u306b\u95a2\u4e0e\u3059\u308b\u5206\u5b50\u306e\u540c\u5b9a\u30fb\u5b9a\u91cf\u5316\u306b\u3082\u6ce8\u529b\u3057\u3001\u5206\u5b50\u30ec\u30d9\u30eb\u3067\u306e\u56e0\u679c\u95a2\u4fc2\u306e\u89e3\u660e\u3068\u5275\u85ac\u7684\u610f\u7fa9\u306e\u660e\u78ba\u5316\u3092\u76ee\u6307\u3057\u3066\u3044\u307e\u3059\u3002<\/p>\n

\u3057\u304b\u3057\u306a\u304c\u3089\u3001\u5f93\u6765\u306e\u30e1\u30ab\u30ce\u30d0\u30a4\u30aa\u30ed\u30b8\u30fc\u5b9f\u9a13\u306f\u9650\u3089\u308c\u305f\u6570\u306e\u5206\u5b50\u3057\u304b\u5bfe\u8c61\u3068\u3067\u304d\u305a\u3001\u5f97\u3089\u308c\u308b\u60c5\u5831\u3082\u5b9a\u6027\u7684\u3067\u3042\u308b\u3053\u3068\u304c\u591a\u3044\u305f\u3081\u3001\u73fe\u8c61\u306e\u7d71\u4e00\u7684\u7406\u89e3\u3084\u5c06\u6765\u7684\u306a\u4e88\u6e2c\u30e2\u30c7\u30eb\u306e\u69cb\u7bc9\u306b\u306f\u4e0d\u5341\u5206\u3067\u3057\u305f\u3002\u3053\u308c\u306b\u5bfe\u3057\u5f53\u7814\u7a76\u5ba4\u3067\u306f\u3001\u7269\u7406\u30e2\u30c7\u30eb\u3068\u5206\u5b50\u89e3\u6790\u3092\u7d71\u5408\u3059\u308b\u3053\u3068\u3067\u3001\u5206\u91ce\u6a2a\u65ad\u7684\u306b\u8aac\u5f97\u529b\u306e\u3042\u308b\u7814\u7a76\u3092\u5c55\u958b\u3057\u3066\u3044\u307e\u3059\u3002<\/p>\n

\u305d\u306e\u305f\u3081\u306e\u57fa\u76e4\u6280\u8853\u3068\u3057\u3066\u3001\u30e1\u30ab\u30ce\u30d0\u30a4\u30aa\u7814\u7a76\u306b\u304a\u3051\u308b\u30aa\u30df\u30c3\u30af\u30b9\u7684\u30a2\u30d7\u30ed\u30fc\u30c1\uff08mechanome\/\u30e1\u30ab\u30ce\u30fc\u30e0\u89e3\u6790\uff09\u306e\u5b9f\u73fe\u3092\u76ee\u6307\u3057\u3001\u30cf\u30fc\u30c9\u30a6\u30a7\u30a2\u30fb\u30bd\u30d5\u30c8\u30a6\u30a7\u30a2\u4e21\u9762\u3067\u306e\u30cf\u30a4\u30b9\u30eb\u30fc\u30d7\u30c3\u30c8\u306a\u5b9f\u9a13\u7cfb\u3092\u958b\u767a\u3057\u3066\u3044\u307e\u3059\u3002\u5177\u4f53\u7684\u306b\u306f\u3001\u529b\u5b66\u523a\u6fc0\u306b\u5bfe\u3059\u308b\u7d30\u80de\u306e\u53cd\u5fdc\u3092\u753b\u50cf\u89e3\u6790\u30fb\u6a5f\u68b0\u5b66\u7fd2\u30fb\u81ea\u52d5\u5316\u30b7\u30b9\u30c6\u30e0\u3092\u901a\u3058\u3066\u7db2\u7f85\u7684\u306b\u53d6\u5f97\u3057\u3001\u7d30\u80de\u306e\u300c\u30e1\u30ab\u30ce\u30bf\u30a4\u30d7\uff08mechanotype\uff09\u300d\u3092\u5b9a\u91cf\u5316\u3059\u308b\u3068\u3068\u3082\u306b\u3001\u529b\u5b66\u5fdc\u7b54\u306b\u95a2\u4e0e\u3059\u308b\u30b7\u30b0\u30ca\u30eb\u7d4c\u8def\u3084\u85ac\u5264\u306e\u30b9\u30af\u30ea\u30fc\u30cb\u30f3\u30b0\u306b\u3082\u6d3b\u7528\u3057\u3066\u3044\u307e\u3059\u3002<\/p>\n

\u3053\u306e\u3088\u3046\u306a\u53d6\u308a\u7d44\u307f\u306b\u3088\u308a\u3001\u300c\u30e1\u30ab\u30ce\u30df\u30af\u30b9\uff08Mechanomics\uff09\u300d\u3084\u300c\u30e1\u30ab\u30ce\u30fb\u30d0\u30a4\u30aa\u30a4\u30f3\u30d5\u30a9\u30de\u30c6\u30a3\u30af\u30b9\uff08Mechano-bioinformatics\uff09\u300d\u3068\u3044\u3063\u305f\u65b0\u305f\u306a\u7814\u7a76\u9818\u57df\u3092\u958b\u62d3\u3057\u3001\u7cbe\u5bc6\u533b\u7642\uff08Precision Medicine\uff09\u3078\u306e\u5fdc\u7528\u3084\u5275\u85ac\u6a19\u7684\u306e\u63a2\u7d22\u3001\u500b\u5225\u5316\u6cbb\u7642\u306e\u6307\u91dd\u63d0\u793a\u306a\u3069\u3001\u533b\u5b66\u30fb\u751f\u7269\u5b66\u3078\u306e\u6ce2\u53ca\u7684\u5c55\u958b\u3092\u76ee\u6307\u3057\u3066\u3044\u307e\u3059\u3002<\/p>\n

\u4ee3\u8868\u8ad6\u6587<\/p>\n

Hamaguchi et al., Sci. Rep.<\/strong><\/em> 12, 13818, 2022.<\/p>\n

Nehwa et al.,\u00a0Bioch. Biophys. Res. Commun.<\/em><\/strong>\u00a0521(2), 527-532, 2020.<\/p>\n

Matsui et al.,\u00a0PLoS ONE<\/em><\/strong>\u00a013(9), e0203448, 2018.<\/p>\n

Ichikawa et al., J. Cell Sci.<\/strong><\/em> 130, 3517-3531, 2017.<\/p>\n

Sakane et al., Mol. Biol. Cell<\/em><\/strong>\u00a027(20), 3095-3108, 2016.<\/p>\n

\u2191<\/a><\/p>\n

4) <\/strong>\u88cf\u58f0\u30fb\u52d5\u7269\u767a\u58f0\u306e\u529b\u5b66\u30e1\u30ab\u30cb\u30ba\u30e0<\/b><\/h3>\n

\u5f53\u7814\u7a76\u5ba4\u3067\u306f\u3001\u4eba\u9593\u304a\u3088\u3073\u52d5\u7269\u306e\u767a\u58f0\u73fe\u8c61\u3092\u3001\u529b\u5b66\u30fb\u6d41\u4f53\u529b\u5b66\u30fb\u97f3\u97ff\u5b66\u306e\u8996\u70b9\u304b\u3089\u7406\u8ad6\u7684\u306b\u89e3\u6790\u3057\u3066\u3044\u307e\u3059\u3002\u3053\u308c\u307e\u3067\u306b\u3001\u30d2\u30c8\u306e\u767a\u58f0\u904e\u7a0b\u3092\u6a21\u64ec\u3057\u305f\u4e09\u6b21\u5143\u6570\u5024\u30e2\u30c7\u30eb\u3092\u69cb\u7bc9\u3057\uff08Deguchi et al., 2007, 2011a\uff09\u3001\u58f0\u5e2f\u3092\u69cb\u6210\u3059\u308b\u7b4b\u30fb\u9771\u5e2f\u306a\u3069\u306e\u89e3\u5256\u5b66\u7684\u69cb\u9020\u306b\u57fa\u3065\u304f\u7269\u6027\u3001\u80ba\u304b\u3089\u306e\u547c\u6c17\u6d41\u3068\u306e\u6d41\u4f53\u69cb\u9020\u9023\u6210\u3001\u6c17\u9053\u5185\u306e\u97f3\u97ff\u5171\u9cf4\u3068\u3044\u3063\u305f\u8907\u6570\u8981\u7d20\u3092\u53d6\u308a\u5165\u308c\u3001\u767a\u58f0\u7570\u5e38\uff08\u58f0\u5e2f\u7d50\u7bc0\u306a\u3069\uff09\u304c\u58f0\u306b\u4e0e\u3048\u308b\u5f71\u97ff\u3092\u89e3\u6790\u3057\u3066\u304d\u307e\u3057\u305f\u3002<\/p>\n

\u7279\u306b\u79c1\u305f\u3061\u306f\u3001\u300c\u88cf\u58f0\uff08falsetto\uff09\u300d\u306e\u529b\u5b66\u7684\u8d77\u6e90\u306b\u6ce8\u76ee\u3057\u3001\u5f93\u6765\u306e\u8aac\u660e\u3067\u306f\u4e0d\u5341\u5206\u3068\u3055\u308c\u3066\u304d\u305f\u88cf\u58f0\u306e\u81ea\u52b1\u632f\u52d5\u30e1\u30ab\u30cb\u30ba\u30e0\u306e\u89e3\u660e\u3092\u76ee\u6307\u3057\u3066\u3044\u307e\u3059\u3002\u88cf\u58f0\u306f\u3001\u5de6\u53f3\u306e\u58f0\u5e2f\u304c\u63a5\u89e6\u305b\u305a\u3001\u660e\u77ad\u306a\u7c98\u819c\u6ce2\u52d5\u3082\u4f34\u308f\u305a\u306b\u632f\u52d5\u304c\u6301\u7d9a\u3059\u308b\u7279\u5fb4\u3092\u3082\u3061\u3001\u305d\u306e\u3088\u3046\u306a\u6761\u4ef6\u4e0b\u3067\u306e\u58f0\u5e2f\u306e\u81ea\u767a\u7684\u632f\u52d5\u306e\u767a\u751f\u306f\u3001\u5f93\u6765\u30e2\u30c7\u30eb\u3067\u306f\u3046\u307e\u304f\u8aac\u660e\u3067\u304d\u307e\u305b\u3093\u3067\u3057\u305f\u3002<\/p>\n

\u3053\u306e\u554f\u984c\u306b\u5bfe\u3057\u3066\u5f53\u7814\u7a76\u5ba4\u3067\u306f\u3001\u6d41\u4f53\u529b\u5b66\u306e\u57fa\u672c\u65b9\u7a0b\u5f0f\u306b\u57fa\u3065\u3044\u3066\u3001\u5589\u982d\u5185\u306e\u9ad8\u901f\u6d41\u306b\u9069\u7528\u53ef\u80fd\u306a\u7406\u8ad6\u30e2\u30c7\u30eb\u3092\u72ec\u81ea\u306b\u5c0e\u51fa\u3057\uff08Deguchi and Hyakutake, 2009\uff09\u3001\u305d\u306e\u30e2\u30c7\u30eb\u3092\u7528\u3044\u3066\u88cf\u58f0\u306b\u7279\u6709\u306e\u65b0\u305f\u306a\u81ea\u52b1\u632f\u52d5\u6a5f\u69cb\u3092\u63d0\u6848\u3057\u307e\u3057\u305f\uff08Deguchi, 2011\uff09\u3002\u3053\u306e\u7406\u8ad6\u306f\u3001\u5f93\u6765\u8aac\u660e\u56f0\u96e3\u3067\u3042\u3063\u305f\u88cf\u58f0\u306e\u767a\u751f\u3092\u3001\u6d41\u4f53\u7684\u89b3\u70b9\u304b\u3089\u81ea\u7136\u306b\u5c0e\u304f\u3082\u306e\u3067\u3042\u308a\u3001\u88cf\u58f0\u306e\u529b\u5b66\u7684\u7406\u89e3\u306b\u65b0\u305f\u306a\u8996\u5ea7\u3092\u63d0\u4f9b\u3057\u3066\u3044\u307e\u3059\u3002<\/p>\n

\u73fe\u5728\u306f\u3001\u3053\u306e\u767a\u58f0\u30e1\u30ab\u30cb\u30ba\u30e0\u304c\u30d2\u30c8\u306b\u9650\u3089\u305a\u3001\u9ce5\u985e\u3084\u54fa\u4e73\u985e\u306a\u3069\u591a\u69d8\u306a\u52d5\u7269\u306b\u5171\u901a\u3059\u308b\u767a\u58f0\u6a5f\u69cb\u306e\u4e00\u5f62\u614b\u3067\u3042\u308b\u53ef\u80fd\u6027\u3092\u5ff5\u982d\u306b\u3001\u767a\u58f0\u306b\u304a\u3051\u308b\u529b\u5b66\u7684\u5171\u901a\u539f\u7406\u306e\u666e\u904d\u6027\u3092\u691c\u8a3c\u3059\u308b\u7814\u7a76\u3092\u9032\u3081\u3066\u3044\u307e\u3059\u3002\u5c06\u6765\u7684\u306b\u306f\u3001\u751f\u7269\u9032\u5316\u306b\u304a\u3051\u308b\u767a\u58f0\u5668\u5b98\u306e\u9069\u5fdc\u3084\u591a\u69d8\u6027\u3092\u3001\u529b\u5b66\u30e2\u30c7\u30eb\u3092\u901a\u3058\u3066\u518d\u69cb\u6210\u3059\u308b\u3053\u3068\u3082\u8996\u91ce\u306b\u5165\u308c\u3066\u3044\u307e\u3059\u3002<\/p>\n

\u4ee3\u8868\u8ad6\u6587<\/p>\n

Deguchi et al.,\u00a0J. Voice<\/em><\/strong>\u00a025, e255-e263, 2011.<\/p>\n

Deguchi et al.,\u00a0PLoS ONE<\/em><\/strong> 6, e17503, 2011.<\/p>\n

Deguchi et al.,\u00a0J. Biomech.<\/em><\/strong>\u00a042, 824-829, 2009.<\/p>\n

Deguchi et al.,\u00a0Ann. Otol. Rhinol. Laryngol.<\/em><\/strong>\u00a0117, 876-880, 2008.<\/p>\n

\u2191<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"

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