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第48回生物機械システム研究会
（兼 基礎工学研究科 機能創成セミナー）
【日時】2017年11月17日（金）10:30-11:30am
【場所】大阪大学基礎工学研究科 C棟4階 C419室
（大阪府豊中市待兼山町 1-3）
http://www.esnew.sakura.ne.jp/ja/access.html
【講演者】Philippe Marcq (Institut Curie)
【演題】Inference of the stress field of a cell sheet
講演概要：
The mechanical behavior of living tissues is deeply connected with many important biological questions, yet little is known about internal tissue mechanics. Since the traction forces exerted by cells on a planar, deformable substrate can be measured, we propose to combine traction force data with Bayesian inversion to estimate the internal stress field of a cell sheet. The method is validated using numerical simulations performed in a wide range of conditions. It is robust to changes in each ingredient of the underlying statistical model. Importantly, its accuracy does not depend on the rheology of the tissue. Combining Bayesian inversion with Kalman filtering allows to process time-lapse movies of the traction force field. As an example of application, we provide an estimate of the tissue stress field close to cell delaminations in an epithelial cell monolayer.