Refereed Journals

Reviews and book chapters



Refereed Journals

(* Corresponding author)

In press

Okamoto, T., Matsui, T.S., Ohishi, T., Deguchi, S.*, Helical structure of actin stress fibers and its possible contribution to inducing their direction-selective disassembly upon cell shortening. Biomechanics and Modeling in Mechanobiology, available online.


Fujiwara, S.*, Matsui, T.S., Ohashi, K., Mizuno, K.*, Deguchi, S.*, Keratin-binding ability of the N-terminal Solo domain of Solo is critical for its function in cellular mechanotransduction. Genes to Cells, 24(5), 390-402, 2019.

Matsui, T.S., Deguchi, S.*, Spatially selective MRLC regulation is absent in dedifferentiated vascular smooth muscle cells but is partially induced by fibronectin and Klf4. American Journal of Physiology Cell Physiology, 316(4), C509-521, 2019.


Matsui, T.S., Ishikawa, A., Deguchi, S.*, Transgelin-1 (SM22α) interacts with actin stress fibers and podosomes in smooth muscle cells without using its actin binding site. Biochemical and Biophysical Research Communications, 505(3), 879-884, 2018.

Matsui, T.S., Wu, H., Deguchi, S.*, Deformable 96-well cell culture plate compatible with high-throughput screening platforms. PLOS ONE, 13(9), e0203448, 2018.

Fujiwara, S.*, Matsui, T.S., Ohashi, K., Deguchi, S.*, Mizuno, K.*,  Solo, a RhoA-targeting guanine nucleotide exchange factor, is critical for hemidesmosome formation and acinar development in epithelial cells. PLOS ONE, 13(4), e0195124, 2018.

Hirose, K., Aoki, T., Furukawa, T., Fukushima, S., Niioka, H., Deguchi, S., Hashimoto, M.*, Coherent anti-Stokes Raman scattering rigid endoscope toward robot-assisted surgery. Biomedical Optics Express, 9(2), 387-396, 2018.


Ichikawa, T., Kita, M., Matsui, T.S., Ichikawa-Nagasato, A., Araki, T., Chiang, S.H., Sezaki, T., Kimura, Y., Ueda, K., Deguchi, S., Saltiel, A.R., Kioka, N.*, Vinexin family (SORBS) proteins play different roles in stiffness-sensing and contractile force generation. Journal of Cell Science, 130, 3517-3531, 2017.
doi: 10.1242/jcs.200691

Fukuda, S.P., Matsui, T.S., Ichikawa, T., Furukawa, T., Kioka, N., Fukushima, S., Deguchi, S.*, Cellular force assay detects altered contractility caused by a nephritis-associated mutation in nonmuscle myosin IIA. Development, Growth & Differentiation, 59(5), 423-433, 2017.
doi: 10.1111/dgd.12379

Deguchi S.*, Saito, A.C., Matsui, T.S., Huang, W.J., Sato, M., The opposite mechano-response of paxillin phosphorylation between subcellular and whole-cell levels is explained by a minimal model of cell–substrate adhesions. Journal of Biomechanical Science and Engineering, 12(2), 16-00670, 2017.
doi: 10.1299/jbse.16-00670

Yokoyama, S., Matsui, T.S., Deguchi, S.*, Microcontact peeling: a cell micropatterning technique for circumventing direct adsorption of proteins to hydrophobic PDMS. Current Protocols in Cell Biology, 75, 10.21.1-10.21.8, 2017.
doi: 10.1002/cpcb.22

Yokoyama, S., Matsui, T.S., Deguchi, S.*, New wrinkling substrate assay reveals traction force fields of leader and follower cells undergoing collective migration. Biochemical and Biophysical Research Communications, 482, 975-979, 2017. [F1000Prime recommended by Faculty of 1000]
doi: 10.1016/j.bbrc.2016.11.142

Ohishi, T., Noda, H., Matsui, T.S., Jile, H., Deguchi, S.*, Tensile strength of oxygen plasma-created surface layer of PDMS. Journal of Micromechanics and Microengineering, 27, 015015, 2017.
doi: 10.1088/0960-1317/27/1/015015


Deguchi, S.*, A possible common physical principle that underlies animal vocalization: theoretical considerations with an unsteady airflow-structure interaction model. Journal of Biomechanical Science and Engineering, 11(4), 16-00414, 2016. [JBSE Papers of the Year]
doi: 10.1299/jbse.16-00414

Sakane, Y., Yoshizawa, S., Nishimura, M., Tsuchiya, Y., Matsushita, N., Miyake, K., Horikawa, K., Imoto, I., Mizuguchi, C., Saito, H., Ueno, T., Matsushita, S., Haga, H., Deguchi, S., Mizuguchi, K., Yokota, H., Sasaki, T.*,  Conformational plasticity of JRAB/MICAL-L2 provides “law and order” in collective cell migration. Molecular Biology of the Cell, 27(20), 3095-3108, 2016.
doi: 10.1091/mbc.E16-05-0332


Deguchi, S.*, Hotta, J., Yokoyama, S., Matsui, T.S., Viscoelastic and optical properties of four different PDMS polymers. Journal of Micromechanics and Microengineering, 25, 097002, 2015.
doi: 10.1088/0960-1317/25/9/097002

Yokoyama, S., Kamei, Y., Matsui, T.S., Deguchi, S.*, Low-power laser processing-based approach to plasma lithography for cell micropatterning. Journal of Bioanalysis and Biomedicine, 7(3), 81–86, 2015.
doi: 10.4172/1948-593X.1000128

Deguchi, S.*, Kudo, S., Matsui, T.S., Huang, W., Sato, M., Piezoelectric actuator-based cell microstretch device with real-time imaging capability. AIP Advances, 5(6), 067110, 2015.
doi: 10.1063/1.4922220


Yokoyama, S., Matsui, T.S., Deguchi, S.*, Microcontact peeling as a new method for cell micropatterning. PLOS ONE, 9(7), e102735, 2014.
doi: 10.1371/journal.pone.0102735

Saito, A.C., Matsui, T.S., Ohishi, T., Sato, M., Deguchi, S.*, Contact guidance of smooth muscle cells is associated with tension-mediated adhesion maturation. Experimental Cell Research, 327(1), 1–11, 2014.
doi: 10.1016/j.yexcr.2014.05.002

Deguchi, S.*, Nagasawa, Y., Saito, A.C., Matsui, T.S., Yokoyama, S., Sato, M., Development of motorized plasma lithography for cell patterning. Biotechnology Letters, 36(3), 507–513, 2014.
doi: 10.1007/s10529-013-1391-3

Saito, A.C., Matsui, T.S., Sato, M., Deguchi, S.*, Aligning cells in arbitrary directions on a membrane sheet using locally formed microwrinkles, Biotechnology Letters, 36(2), 391-396, 2014.
doi: 10.1007/s10529-013-1368-2


Matsui, T.S., Sato, M., Deguchi, S.*, High extensibility of stress fibers revealed by in vitro micromanipulation with fluorescence imaging. Biochemical and Biophysical Research Communications, 434, 444-448, 2013.
doi: 10.1016/j.bbrc.2013.03.093

Deguchi, S.*, Takahashi, S., Hiraki, H., Tanimura, S., Direct measurement of force exerted during single microbubble generation, Applied Physics Letters, 102, 084101, 2013.


Deguchi, S.*, Matsui, T.S., Komatsu, D., Sato, M., Contraction of stress fibers extracted from smooth muscle cells: Effects of varying ionic strength. Journal of Biomechanical Science and Engineering, 7, 388-398, 2012.
doi: 10.1299/jbse.7.388

Deguchi, S.*, Matsui, T.S., Sato, M., Simultaneous contraction and buckling of stress fibers in individual cells. Journal of Cellular Biochemistry, 113, 824-832, 2012.
doi: 10.1002/jcb.23410


Deguchi, S.*, Matsui, T.S., Iio, K., The position and size of individual focal adhesions are determined by intracellular stress-dependent positive regulation. Cytoskeleton, 68, 639-651, 2011.
doi: 10.1002/cm.20541

Deguchi, S.*, Y Kawahara, S Takahashi, Cooperative regulation of vocal fold morphology and stress by the cricothyroid and thyroarytenoid muscles, Journal of Voice, 25, e255-e263, 2011.

Deguchi, S.*, Takahashi, S., Tanimura, S., Hiraki, H., Producing single microbubbles with controlled size using microfiber. Advances in Bioscience and Biotechnology, 2, 385-390, 2011.

Deguchi, S.*, Bamba, H., Measuring surface geometry of adherent cells using oblique transillumination. Advances in Bioscience and Biotechnology, 2, 359-363, 2011.

Deguchi, S.*, Kawahara, Y., Simulation of human phonation with vocal nodules. Am. J. Comp. Math., 1, 189-201, 2011.

Matsui, T.S., Kaunas, R., Kanzaki, M., Sato, M., Deguchi, S.*, Non-muscle myosin II induces disassembly of actin stress fibres independently of myosin light chain dephosphorylation. Interface Focus, 1, 754-766, 2011. (Selected for the cover art of the issue)
doi: 10.1098/rsfs.2011.0031

Kaunas, R.*, Deguchi, S., Multiple roles for myosin II in tensional homeostasis under mechanical loading, Cellular and Molecular Bioengineering, 4, 182-191, 2011.

Deguchi, S.*, Mechanism of and threshold biomechanical conditions for falsetto voice onset, PLoS ONE 6, e17503, 2011.

Kaunas, R.*, Hsu, H., Deguchi, S., Sarcomeric model of stretch-induced stress fiber reorganization, Cell Health and Cytoskeleton, 3, 13-22, 2011.


C. Lee, C. Haase, S. Deguchi, R. Kaunas*, Cyclic stretch-induced stress fiber dynamics – Dependence on strain rate, rho kinase and MLCK, Biochemical and Biophysical Research Communications, 401, 344-349, 2010.

T.S. Matsui, K. Ito, R. Kaunas, M. Sato, S. Deguchi*, Actin stress fibers are at a tipping point between conventional shortening and rapid disassembly at physiological levels of MgATP, Biochemical and Biophysical Research Communications, 395, 301-306, 2010.
doi: 10.1016/j.bbrc.2010.03.150


S. Deguchi*, M. Sato, Biomechanical properties of actin stress fibers of non-motile cells. Biorheology, 46, 93-105, 2009.

T.S. Matsui*, S. Deguchi, N. Sakamoto, T. Ohashi, M. Sato, A versatile micro-mechanical tester for actin stress fibers isolated from cells. Biorheology, 46, 401-415, 2009.
doi: 10.3233/BIR-2009-0551

S Deguchi*, T Hyakutake, Theoretical consideration of the flow behavior in oscillating vocal fold, Journal of Biomechanics, 42, 824-829, 2009.

S Deguchi*, Y Ishimaru, K Hashimoto, S Washio, K Tsujioka, Measurement and finite element modeling of the force balance in the vertical section of adhering vascular endothelial cells. Journal of the Mechanical Behavior of Biomedical Materials, 2, 173-185, 2009.


S Washio*, S Takahashi, K Murakami, T Tada, S Deguchi, Cavity generation by accelerated relative motions between solid walls contacting in liquid. Proc. IMechE, Part C, Journal of Mechanical Engineering Science, 222, 1695-1706, 2008.

S Washio*, S Takahashi, K Murakami, T Tada, S Deguchi, Cavity generation by accelerated relative motions between solid walls contacting in liquid. Trans Jpn Soc Mech Eng B, 74, 1376-1385, 2008.

S Deguchi* and K Kawashima, Computer-aided technique for automatic determination of the relationship between transglotatl pressure change and voice fundamental frequency. Annals of Otology, Rhinology & Laryngology, 117, 876-880, 2008.


S Deguchi*, Y Ishimaru, S Washio, Preliminary evaluation of stroboscopy system using multiple light sources for observation of pathological vocal fold oscillatory pattern, Annals of Otology, Rhinology & Laryngology, Vol 116, 9, 687-694, 2007.

S. Deguchi*, M. Yano, K. Hashimoto, H. Fukamachi, S. Washio, K. Tsujioka, Assessment of the mechanical properties of the nucleus inside a spherical endothelial cell based on micro-tensile testing. Journal of Mechanics of Materials and Structures, Vol 2, No 6, 1087-1102, 2007.

S. Deguchi*, Y. Matsuzaki, T. Ikeda, Numerical analysis of effects of transglottal pressure change on fundamental frequency of phonation. Annals of Otology, Rhinology & Laryngology, Vol 116, No 2, 128-134, 2007.


T. Hyakutake*, S. Deguchi, A. Shiota, Y. Nishioka, S. Yanase, S. Washio, Effect of constriction oscillation on flow for potential application to vocal fold mechanics: numerical analysis and experiment. Journal of Biomechanical Science and Engineering, Vol. 1, No. 2, 290-303, 2006.

S. Deguchi*, Y. Miyake, Y. Tamura, S. Washio, Wavelike motion of a mechanical vocal fold model at the onset of self-excited oscillation. Journal of Biomechanical Science and Engineering, Vol 1, No 1, 246-255, 2006.

S. Deguchi*, T. Ohashi, M. Sato, Tensile properties of single stress fibers isolated from cultured vascular smooth muscle cells. Journal of Biomechanics, 39, 2603-2610, 2006.


Deguchi, S. *, Ishimaru, Y., Washio, S., Laryngo-stroboscopy for observation of pathological vocal fold oscillation, Transactions of the Japanese Society for Medical and Biological Engineering 43, 4, 709-716, 2005.

S. Deguchi*, T. Ohashi, M. Sato, Intracellular stress transmission through actin stress fiber network in adherent vascular cells. Mol Cell Biomech, Vol 2, No 4, 205-216, 2005.

S. Deguchi*, T. Ohashi, M. Sato, Evaluation of tension in actin bundle of endothelial cells based on preexisting strain and tensile properties measurements. Mol Cell Biomech, Vol 2, No 3, 125-134, 2005.

S. Deguchi*, T. Ohashi, M. Sato, Newly designed tensile test system for in vitro measurement of mechanical properties of cytoskeletal filaments. JSME International Journal Series C, Vol 48, No 4, 396-402, 2005. (Awarded JSME Medal for Outstanding Paper by the Japan Society of Mechanical Engineers)

S. Deguchi*, K. Maeda, T. Ohashi, M. Sato, Flow-induced hardening of endothelial nuclei as an intracellular stress-bearing organelle. Journal of Biomechanics, 38, 1751-1759, 2005. [F1000Prime recommended by Faculty of 1000]


Sato, M.*, Sakamoto, N., Deguchi, S., Katoh, M., and Abe, K., Vitamin E inhibits leukocyte adhesion and platelet aggregation, Jpn J Med Pharm Sci, 47, 457-461, 2002.


Reviews and book chapters

出口 真次,松井 翼,市川 尚文,木岡 紀幸,細胞収縮力アッセイ, 月刊「細胞」, 51(3), 39-42, 2019.

出口 真次,松井 翼,市川 尚文,木岡 紀幸,細胞収縮力のアッセイ − メカノバイオロジー研究のツール,Precision Medicine プレシジョンメディシンと創薬,北隆館 ニューサイエンス社,2018.

出口真次,4.4 バイオテクノロジー・バイオインフォマティクス,機械工学年鑑2018

出口真次, 高度物理刺激と生体応答. 2.2.7節 細胞の力学応答における張力ホメオスタシスの役割. 養賢堂, 2017.

出口真次, 細胞のマルチスケールメカノバイオロジー. 第4章 細胞接着のメカノバイオロジー: 細胞収縮性に依存した機能調節の仕組み. 森北出版, 2017.

Kaunas, R., Deguchi, S., Cyclic stretch-induced reorganization of stress fibers in endothelial cells. In Vascular Engineering. Eds: Tanishita, K., Yamamoto, K., Springer, 99-110, 2016.

出口真次, 松井翼, 佐藤正明, Dojin Bioscienceシリーズ・メカノバイオロジー. 細胞が力を感じ応答する仕組み. 第2章 細胞における力の発生と維持機構. 17-33, 2015.

佐藤正明, 出口真次, 安達泰治, 村上輝夫, 廣川 俊二, バイオメカニクスの最前線(機械工学の最前線7), 共立出版, 2013.

出口真次, 細胞における力の発生とバランス, 細胞工学, 31, 988-993, 2012.

Deguchi, S., Sato, M., Nuclear mechanics and mechanotransduction. In Cellular Mechanotransduction: Diverse Perspectives from Molecules to Tissues. Eds: Mofrad, M.R.K., Kamm, R.D., Cambridge University Press, 220-233, 2010.

Sato, M., Deguchi, S., Biomechanics of an isolated single stress fiber. In Tributes to Yuan-Cheng Fung on His 90th Birthday. Eds: Chien, S., et al., World Scientific, 13-20, 2010.

Matsui, T., Deguchi, S., Sakamoto, N., Ohashi, T., Sato, M., The effect of ATP on force of isolated actin stress fibers exposed to step strain. In Nano-biomedical engineering 2009. Ed: Yamaguchi, T., Imperial College Press, 77-82, 2009.

出口真次, 佐藤正明, アクチンストレスファイバのマイクロ・ナノバイオメカニクス, 生体医工学, 4611-15, 2008.

Deguchi, S., Ohashi, T., Sato, M., Experimental estimation of preexisting tension in single actin stress fiber of vascular cells. In Biomechanics at Micro- and Nanoscale Levels, Vol. 4. Ed: Wada, H., World Scientific, 60-71, 2007.

Deguchi, S., Ohashi, T., Sato, M., Mechanical properties properties of stress fiber in adherent vascular cells characterized by in vitro micromanipulation;

Matsui, T., Deguchi, S., Ohashi, T., Sato, M., Effect of strain rate on tensile properties of stress fibers isolated from cultured smooth muscle cells; In Future Medical Engineering Based on Bionanotechnology. Eds: Esashi, M., et al., Imperial College Press, 71-78, 129-135, 2006.