Chwee Teck (C.T.) Lim PhD
Provost’s Chair Professor
Department of Biomedical Engineering and Mechanobiology Institute
National University of Singapore
Mechanobiology of Collective Cell Migration in Health and Disease
Cells migrating in sheets or large cohorts tend to behave very differently from cells migrating individually. Such distinctive behavior of cells migrating in a collective manner underlies several important biological processes such as wound closure, maintenance of intestinal epithelium, developmental processes and even cancer metastasis. As such, they can also provide important insights towards better tissue repair and regenerative medicine. Here, we characterized the kinematic behavior of epithelial cell cohorts migrating under well defined geometrical constraints. We also studied collective cell migration over areas without cell adherent proteins to examine the formation of epithelial bridges so as to better wound closure mechanisms. Finally, we examined the collective migration of benign, non-invasive malignant and highly-invasive malignant cancer cells so as to better understand metastatic induced migration.
- Saw et al., Topological defects in epithelia govern cell death and extrusion, Nature, 2017.
- Vedula et al., Mechanics of epithelial closure over non-adherent environments, Nature Communications, 2015.
- Vedula et al., Epithelial bridges maintain tissue integrity during collective cell migration, Nature Materials, 2014.
- Vedula et al., Emerging modes of collective cell migration induced by geometrical constraints, PNAS, 2012.